Kirito (Sword art Online) vs The Boss (Saints Row). If you have a UniVS template with a picture of the two to replace the pictures, feel free. Comment your opinion on who would win and if you'd like to see this as an episode.
They are both characters trapped in a life or death struggle fighting in a virtual world. The world they inhabit gives them powers beyond what they could ever do in the real world. One operates in a virtual fantasy world, while the others virtual prison is based off of science fiction. For some reason, Kirito has a bunch of girls flocking to his side, although a joke, you can technically "romance" any of your crewmates at any time in Saints Row 4, meaning The Boss has as many potential romances as Kirito. Also, they were both asked by the government to stop elusive criminals, Death Gun for Kirito, and Cyrus Temple for The Boss.
Now assuming this battle takes place in the virtual world, anything but intelligence feats for The Boss can't be included before Saints Row 4, since it's technically not the same body being used as the virtual one. The Boss has an overwhelming arsenal, but with Kirito fast enough to deflect a barrage of bullets, I don't think guns will do the trick. However the boss has a wide variety of superpowers, Kirito doesn't have as many, but has had more experience for them. This battle depends on one factor, can Kirito use his speed advantage to avoid or block The Bosses diverse power set and get a killing blow, or will The Boss be able to overwhelm Kirito with sheer number of abilities. I'm personally betting on Kirito, due to his intelligence advantage over The Boss, and his natural speed compared to The Bosses limited speed power.